Makai’s Technology is underpinned by peer-reviewed, scientific studies, NIH funding and an issued US and international patent.

 

TRPV1 is a component of the atrial natriuretic signaling complex, and using orally delivered antagonists, presents a valid therapeutic target in the longitudinal reversal and treatment of cardiac hypertrophy and heart failure.

Horton JS, Shiraishi T, Alfulaij N, Small-Howard AL, Turner HC, Kurokawa T, Mori Y, Stokes AJ.

Channels (Austin). 2019 Dec;13(1):1-16. doi: 10.1080/19336950.2018.1547611.

PMID: 30424709

 

Mice lacking functional TRPV1 are protected from pressure overload cardiac hypertrophy.

Buckley CL, Stokes AJ.

Channels (Austin). 2011 Jul-Aug;5(4):367-74. doi: 10.4161/chan.5.4.17083. Epub 2011 Jul 1.

PMID: 21814047

Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice.

Horton JS, Buckley CL, Stokes AJ.

Channels (Austin). 2013 Jan 1;7(1):17-22. doi: 10.4161/chan.23006. Epub 2012 Dec 6.

PMID: 23221478 

 

The calcium release-activated calcium channel Orai1 represents a crucial component in hypertrophic compensation and the development of dilated cardiomyopathy.

Horton JS, Buckley CL, Alvarez EM, Schorlemmer A, Stokes AJ.

Channels (Austin). 2014;8(1):35-48. doi: 10.4161/chan.26581. Epub 2013 Oct 17.

PMID: 24135962 

Corin-deficient W-sh mice poorly tolerate increased cardiac afterload.

Buckley CL, Stokes AJ.

Regul Pept. 2011 Dec 10;172(1-3):44-50. doi: 10.1016/j.regpep.2011.08.006. Epub 2011 Sep 6.

PMID: 21903139.

 

Cannabinoids, the Heart of the Matter.

Alfulaij N, Meiners F, Michalek J, Small-Howard AL, Turner HC, Stokes AJ.

J Am Heart Assoc. 2018 Jul 13;7(14):e009099. doi: 10.1161/JAHA.118.009099.

PMID: 30006489

Diverse TRPV1 responses to cannabinoids.

Starkus J, Jansen C, Shimoda LMN, Stokes AJ, Small-Howard AL, Turner H.

Channels (Austin). 2019 Dec;13(1):172-191. doi: 10.1080/19336950.2019.1619436.

PMID: 31096838

 

LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability.

Nadler MJ, Hermosura MC, Inabe K, Perraud AL, Zhu Q, Stokes AJ, Kurosaki T, Kinet JP, Penner R, Scharenberg AM, Fleig A.

Nature. 2001 May 31;411(6837):590-5. doi: 10.1038/35079092.

PMID: 11385574

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Myrcene and terpene regulation of TRPV1.

Jansen C, Shimoda LMN, Kawakami JK, Ang L, Bacani AJ, Baker JD, Badowski C, Speck M, Stokes AJ, Small-Howard AL, Turner H.

Channels (Austin). 2019 Dec;13(1):344-366. doi: 10.1080/19336950.2019.1654347.

PMID: 3144683

 

 ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology.

Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM.

Nature. 2001 May 31;411(6837):595-9. doi: 10.1038/35079100.

PMID: 11385575

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US20170231982A1

Methods and compositions for prevention and treatment of cardiac hypertrophy

https://www.hawaii.edu/news/2015/08/25/heart-failure-therapy-patent-awarded-to-medical-school-researcher/

https://www.bizjournals.com/pacific/news/2015/08/14/university-of-hawaii-medical-school-researcher.html

https://www.linkedin.com/pulse/gb-sciences-licenses-patent-from-makai-biotechnology-develop-stokes/

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Grants that have funded our research

  • NIH U54MD007584 RMATRIX (Research Centers in Minority Institutions. Multidisciplinary And Translational Research Infrastructure Expansion)

  • NIH BRIC P20 MD0006084 (Biomedical Research Infrastructure and Capacity Building)

  • Hawaii Community Foundation Geist Foundation for Medical Research

  • NIH COBRE P20GM113134 (Center for Biomedical Research Excellence)

  • NIH INBRE P20RR016467 (IDeA Network for Biomedical Research Excellence)